Aduro Biotech and Novartis Present Results from Ongoing Phase 1b Study of STING Agonist ADU-S100 (MIW815) in Combination with Anti-PD-1 Monoclonal Antibody Spartalizumab (PDR001) in Patients with Advanced Solid Tumors or Lymphomas

Jun 02, 2019

ADU-S100 (MIW815) + spartalizumab combination data demonstrated antitumor activity in anti-PD-1-naïve triple-negative breast cancer (TNBC) and previously immunotherapy-treated melanoma
As of the April 5, 2019 data cut-off, five patients treated in the weekly dosing schedule group achieved confirmed responses, one of which was a complete response (CR)
Of the eight TNBC patients evaluable for efficacy, one anti-PD-1 naïve TNBC patient achieved a CR and two anti-PD-1 naïve TNBC patients achieved partial responses (PRs)
Of the 25 melanoma patients radiologically evaluable for efficacy, two previously immunotherapy-treated melanoma patients achieved PRs

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