Allogene Therapeutics Presents Updated ALLO-501/501A Phase 1 Data in Large B Cell Lymphoma at the American Society of Clinical Oncology (ASCO) Annual Meeting

Jun 03, 2023

Long Term Follow Up Data from Phase 1 ALPHA/ALPHA2 Trials Demonstrate Potential of Allogeneic CD19 CAR T to Generate Durable Complete Responses Similar to Approved Autologous Therapies
- Presentation Focused on Patients (n=12) Treated with Phase 2 Regimen
- 67% Overall Response Rate (ORR) and 58% Complete Response (CR) Rate
- Five Patients (42%) Maintained a CR at Month 6; Four of Five CRs (80%) Ongoing Beyond Six Months, Including Two at 30+ Months and One at 24+ Months
Clinical Safety and Immune Recovery Comparable to Autologous Therapies
Robust AlloCAR T Cell Expansion and Persistence Documented in Responding Patients
Allogeneic CAR T Treatment Initiated at a Median of Three Days After Enrollment Without Need for Leukapheresis or Bridging Therapy; 100% Received Allogeneic CAR T Product Candidates Meeting Manufacturing Specifications
Enrollment in Potentially Pivotal Phase 2 ALPHA2 Trial Ongoing with Expected Completion 1H2024

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