AlloVir, Inc. (Nasdaq: ALVR), a late-clinical stage allogeneic T-cell immunotherapy company, today announced final data from the Phase 2 study of posoleucel, an investigational, allogeneic, off-the-shelf, multi-virus specific T cell therapy, for the prevention of clinically significant infections or diseases from six common and devastating viruses in allogeneic hematopoietic cell transplant (allo-HCT) recipients – adenovirus (AdV), BK virus (BKV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus-6 (HHV-6) and JC virus (JCV). These final data demonstrated a substantial reduction in the expected rate of clinically significant viral infections or diseases in this high-risk patient population despite the expected high rates of viral reactivation. Biomarker data demonstrated the persistence of posoleucel and association between expansion of functional virus-specific T cells (VSTs) and viral control. Repeat dosing of posoleucel was generally well tolerated in the study. These data were highlighted in an oral presentation (Abstract+362) at the 64th American Society of Hematology (ASH) Annual Meeting and Exposition in New Orleans today.
AlloVir Announces Positive Final Results in Phase 2 Posoleucel Multi-Virus Prevention Study In Oral Presentation at the 64th ASH Annual Meeting and Exposition
Dec 10, 2022
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