BAKER BROS. ADVISORS LP

The estimated net worth of BAKER BROS. ADVISORS LP is at least $17,038 Million dollars as of 06/29/2022. BAKER BROS. ADVISORS LP is the Director, 10% Owner of ACADIA Pharmaceuticals Inc. BAKER BROS. ADVISORS LP owns over 38,536,853 shares of ACADIA Pharmaceuticals Inc stock worth over $547 Million . BAKER BROS. ADVISORS LP is the Director of Alexion Pharmaceuticals Inc. BAKER BROS. ADVISORS LP owns over 7,927,481 shares of Alexion Pharmaceuticals Inc stock worth over $1,446 Million . BAKER BROS. ADVISORS LP is the Director of Neoleukin Therapeutics Inc. BAKER BROS. ADVISORS LP owns over 3,503,951 shares of Neoleukin Therapeutics Inc stock worth over $3 Million . BAKER BROS. ADVISORS LP is the 10% Owner of BioCryst Pharmaceuticals Inc. BAKER BROS. ADVISORS LP owns over 9,441,849 shares of BioCryst Pharmaceuticals Inc stock worth over $102 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of BeiGene Ltd. BAKER BROS. ADVISORS LP owns over 10,728,961 shares of BeiGene Ltd stock worth over $1,741 Million . BAKER BROS. ADVISORS LP is the 10% Owner of Bellicum Pharmaceuticals Inc. BAKER BROS. ADVISORS LP owns over 5,813 shares of Bellicum Pharmaceuticals Inc stock worth over $7,033.73. BAKER BROS. ADVISORS LP is the Director of Idera Pharmaceuticals Inc. BAKER BROS. ADVISORS LP owns over 2,319,324 shares of Idera Pharmaceuticals Inc stock worth over $1 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of Incyte Corp. BAKER BROS. ADVISORS LP owns over 66,793,259 shares of Incyte Corp stock worth over $5,068 Million . BAKER BROS. ADVISORS LP is the 10% Owner of Mirati Therapeutics Inc. BAKER BROS. ADVISORS LP owns over 30,140 shares of Mirati Therapeutics Inc stock worth over $2 Million . BAKER BROS. ADVISORS LP is the of Intellia Therapeutics Inc. BAKER BROS. ADVISORS LP owns over 976,214 shares of Intellia Therapeutics Inc stock worth over $51 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of Seagen Inc. BAKER BROS. ADVISORS LP owns over 42,970,781 shares of Seagen Inc stock worth over $7,694 Million . BAKER BROS. ADVISORS LP is the 10% Owner of Invitae Corp. BAKER BROS. ADVISORS LP owns over 7,553,553 shares of Invitae Corp stock worth over $19 Million . BAKER BROS. ADVISORS LP is the of Rhythm Pharmaceuticals Inc. BAKER BROS. ADVISORS LP owns over 1,878,242 shares of Rhythm Pharmaceuticals Inc stock worth over $8 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of Kiniksa Pharmaceuticals Ltd. BAKER BROS. ADVISORS LP owns over 3,000,000 shares of Kiniksa Pharmaceuticals Ltd stock worth over $29 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of Kodiak Sciences Inc. BAKER BROS. ADVISORS LP owns over 17,310,490 shares of Kodiak Sciences Inc stock worth over $137 Million . BAKER BROS. ADVISORS LP is the of HOOKIPA Pharma Inc. BAKER BROS. ADVISORS LP owns over 820,729 shares of HOOKIPA Pharma Inc stock worth over $1 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of IGM Biosciences Inc. BAKER BROS. ADVISORS LP owns over 3,144,000 shares of IGM Biosciences Inc stock worth over $57 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of Prelude Therapeutics Inc. BAKER BROS. ADVISORS LP owns over 9,247,763 shares of Prelude Therapeutics Inc stock worth over $47 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of Talis Biomedical Corp. BAKER BROS. ADVISORS LP owns over 7,625,425 shares of Talis Biomedical Corp stock worth over $6 Million . BAKER BROS. ADVISORS LP is the Director, 10% Owner of TScan Therapeutics Inc. BAKER BROS. ADVISORS LP owns over 2,784,792 shares of TScan Therapeutics Inc stock worth over $8 Million . BAKER BROS. ADVISORS LP is the 10% Owner of Entrada Therapeutics Inc. BAKER BROS. ADVISORS LP owns over 4,865,819 shares of Entrada Therapeutics Inc stock worth over $62 Million .

BAKER BROS. ADVISORS LP mailing address: 860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

Insider Roles

Name	Transaction Date	Position
IGM Biosciences Inc	2022-03-12	director, 10 percent owner
Incyte Corp	2012-04-12	director, 10 percent owner
Kodiak Sciences Inc	2022-01-21	director, 10 percent owner
Prelude Therapeutics Inc	2020-09-24	director, 10 percent owner
Kiniksa Pharmaceuticals Ltd	2018-05-23	director, 10 percent owner
Atreca Inc	2019-06-19	10 percent owner
BeiGene Ltd	2016-02-02	director, 10 percent owner
ACADIA Pharmaceuticals Inc	2012-12-12	10 percent owner
Seagen Inc	2020-12-31	director, 10 percent owner
Alexion Pharmaceuticals Inc	2020-05-14	director
Zymeworks Inc	2020-03-16	director
Neoleukin Therapeutics Inc	2015-08-07	10 percent owner
Idera Pharmaceuticals Inc	2014-03-10	director
HOOKIPA Pharma Inc	2019-04-17	10 percent owner
Principia Biopharma Inc	2018-09-13	10 percent owner
Invitae Corp	2015-08-27	10 percent owner
Bellicum Pharmaceuticals Inc	2015-12-24	10 percent owner
Mirati Therapeutics Inc	2013-07-09	10 percent owner
Rhythm Pharmaceuticals Inc	2017-10-04	10 percent owner
BioCryst Pharmaceuticals Inc	2012-04-12	10 percent owner
Intellia Therapeutics Inc	2016-05-05	10 percent owner
XOMA Corp	2012-04-12	10 percent owner
XOMA Corp	2012-04-12	10 percent owner
Talis Biomedical Corp	2021-11-18	director, 10 percent owner
DBV Technologies SA	2021-01-01	director, 10 percent owner
Aeglea BioTherapeutics Inc	2021-02-23	director
Entrada Therapeutics Inc	2022-05-16	10 percent owner
TScan Therapeutics Inc	2022-05-10	director, 10 percent owner

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BAKER BROS. ADVISORS LP trading performance

Average Relative Return

39.98%

Average relative return per transaction

Outperforming Transactions

62%

26 out of 42 outperforming transactions.

Each transaction is measured over a period and compared to .

BAKER BROS. ADVISORS LP trading performance analysis

	1 Month	3 Months	6 Months	1 Year	2 Years	3 Years
Relative Return(%)	-2.55	3.1	12.45	39.98	46.82	21.04
Relative Return to S&P 500(%)	-4.63	-3.01	3.86	27.15	19.22	-16.28

Baker Bros. Advisors Lp trading transactions

Ticker	Company	Current Price	Insider Name	Insider Position	Date	Buy/Sell	Insider Trading Shares	Shares Change	Price	Cost	Final Share	Price Change Since Insider Trade (%)	Filing Date	Dividend Yield %	PE Ratio	Market Cap ($M)
Ticker	Company	Current Price	Insider Name	Insider Position	Date	Buy/Sell	Insider Trading Shares	Shares Change	Price	Cost	Final Share	Price Change Since Insider Trade (%)	Filing Date	Dividend Yield %	PE Ratio	Market Cap ($M)
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-06-06	Buy	572,349	3.42%	$7.77	$4,447,150	17,310,490	1.93%	2022-06-06	0	At Loss	407.37
TRDA	Entrada Therapeutics Inc	$12.94	BAKER BROS. ADVISORS LP	10% Owner	2022-06-06	Buy	40,947	0.85%	$6.37	$260,832	4,865,819	103.14%	2022-06-06	0	At Loss	356
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-05-27	Buy	350,406	2.14%	$6.75	$2,365,240	16,738,141	17.33%	2022-05-27	0	At Loss	407.37
TRDA	Entrada Therapeutics Inc	$12.94	BAKER BROS. ADVISORS LP	10% Owner	2022-05-24	Buy	48,509	1.02%	$5.82	$282,322	4,824,872	122.34%	2022-05-24	0	At Loss	356
TRDA	Entrada Therapeutics Inc	$12.94	BAKER BROS. ADVISORS LP	10% Owner	2022-05-18	Buy	71,944	1.53%	$5.99	$430,945	4,776,363	116.03%	2022-05-18	0	At Loss	356
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-05-18	Buy	456,690	2.87%	$5.91	$2,699,040	16,387,735	34.01%	2022-05-18	0	At Loss	407.37
TCRX	TScan Therapeutics Inc	$3.10	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-05-11	Buy	1,359,792	95.42%	$1.88	$2,556,410	2,784,792	64.89%	2022-05-12	0	At Loss	72.81
INCY	Incyte Corp	$75.89	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-03-10	Buy	389,080	0.59%	$72.24	$28,107,100	66,793,259	5.05%	2022-03-10	0	18.02	16,772.36
INCY	Incyte Corp	$75.89	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-02-22	Buy	525,804	1.46%	$67.96	$35,733,600	36,524,495	11.67%	2022-02-22	0	18.02	16,772.36
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-02-17	Buy	400,965	2.58%	$54.45	$21,832,500	15,931,045	-85.45%	2022-02-17	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-01-31	Buy	347,665	2.29%	$52.02	$18,085,500	15,530,080	-84.78%	2022-01-31	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2022-01-25	Buy	501,111	3.41%	$57.49	$28,808,900	15,182,415	-86.22%	2022-01-25	0	At Loss	407.37
INCY	Incyte Corp	$75.89	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-12-17	Buy	1,595,519	4.86%	$72.43	$115,563,000	34,399,479	4.78%	2021-12-17	0	18.02	16,772.36
SGEN	Seagen Inc	$179.06	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-12-01	Sell	394,895	-0.91%	$160.54	$63,396,400	42,970,781	11.54%	-	0	At Loss	33,476.16
TLIS	Talis Biomedical Corp	$0.82	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-11-18	Buy	50,000	0.66%	$4.37	$218,500	7,625,425	-81.21%	-	0	At Loss	21.93
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-09-30	Buy	86,932	0.60%	$95.83	$8,330,690	14,681,304	-91.74%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-09-16	Buy	31,838	0.22%	$94.39	$3,005,190	14,444,389	-91.61%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-09-07	Buy	57,501	0.40%	$93.31	$5,365,420	14,412,551	-91.51%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-08-19	Buy	114,396	0.80%	$87.50	$10,009,600	14,355,050	-90.95%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-08-13	Buy	102,773	0.73%	$87.19	$8,960,780	14,240,654	-90.92%	-	0	At Loss	407.37
TCRX	TScan Therapeutics Inc	$3.10	BAKER BROS. ADVISORS LP	Director	2021-07-20	Buy	1,425,000	0%	$15	$21,375,000	1,320,302	-79.33%	-	0	At Loss	72.81
TLIS	Talis Biomedical Corp	$0.82	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-02-17	Buy	6,250,000	829.17%	$16	$100,000,000	7,003,766	-94.87%	-	0	At Loss	21.93
BGNE	BeiGene Ltd	$162.29	BAKER BROS. ADVISORS LP	Director, 10% Owner	2021-01-04	Sell	121,154	-1.12%	$220.50	$26,714,500	10,728,961	-26.40%	-	0	At Loss	17,090.90
BGNE	BeiGene Ltd	$162.29	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-12-04	Sell	1,511,546	-12.25%	$220.50	$333,296,000	10,829,638	-26.40%	-	0	At Loss	17,090.90
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-11-20	Buy	1,527,777	13.63%	$108	$165,000,000	12,736,556	-92.67%	-	0	At Loss	407.37
PRLD	Prelude Therapeutics Inc	$5.18	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-09-29	Buy	1,578,947	20.59%	$19	$30,000,000	9,247,763	-72.74%	-	0	At Loss	241.82
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-09-25	Buy	48,125	0.39%	$56.65	$2,726,280	12,352,175	-86.02%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-09-24	Buy	203,047	1.68%	$51.71	$10,499,600	12,304,050	-84.68%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-09-08	Buy	322,979	2.74%	$47.43	$15,318,900	12,101,003	-83.30%	-	0	At Loss	407.37
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-08-21	Buy	203,486	1.76%	$48.23	$9,814,130	11,778,024	-83.58%	-	0	At Loss	407.37
NLTX	Neoleukin Therapeutics Inc	$1.02	BAKER BROS. ADVISORS LP	Director	2020-07-07	Buy	424,000	13.77%	$15.25	$6,466,000	3,503,951	-93.31%	-	0	At Loss	42.19
SGEN	Seagen Inc	$179.06	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-05-15	Sell	1,750,000	-1.98%	$160	$280,000,000	86,760,740	11.91%	-	0	At Loss	33,476.16
SGEN	Seagen Inc	$179.06	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-05-08	Sell	1,058,316	-2.29%	$161.85	$171,288,000	45,072,881	10.63%	-	0	At Loss	33,476.16
ACAD	ACADIA Pharmaceuticals Inc	$14.22	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-03-18	Buy	1,050,000	2.80%	$32.05	$33,652,500	38,536,853	-55.63%	-	0	At Loss	2,339.77
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-03-18	Buy	150,000	1.31%	$39.29	$5,893,500	11,574,538	-79.84%	-	0	At Loss	407.37
ALXN	Alexion Pharmaceuticals Inc	$182.50	BAKER BROS. ADVISORS LP	Director	2020-03-18	Buy	81,379	1.03%	$82.01	$6,673,890	8,002,119	122.53%	-	0	59.16	40,336.01
ALXN	Alexion Pharmaceuticals Inc	$182.50	BAKER BROS. ADVISORS LP	Director	2020-03-18	Buy	418,621	5.58%	$78.33	$32,790,600	7,927,481	132.99%	-	0	59.16	40,336.01
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2020-02-26	Buy	377,249	3.41%	$57.87	$21,831,400	11,424,538	-86.31%	-	0	At Loss	407.37
NLTX	Neoleukin Therapeutics Inc	$1.02	BAKER BROS. ADVISORS LP	Director	2019-12-20	Buy	3,017,542	23.28%	$8.40	$25,347,400	15,982,255	-87.86%	-	0	At Loss	42.19
KOD	Kodiak Sciences Inc	$7.92	BAKER BROS. ADVISORS LP	Director, 10% Owner	2019-12-06	Buy	1,902,173	20.80%	$46	$87,500,000	11,047,289	-82.78%	-	0	At Loss	407.37

Total 121

Only the transactions in Open Market or Private Sale at the market prices are included. Other transactions such as conversion of derivative security or exercise of options are not included. Insiders are limited to only officers and/or directors of the company.

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